Introduction to Bioinformatics, Review on Biological Databases concept: Primary, secondary and composite databases, Nucleotide Sequence databases (EMBL, GenBank, DDBJ) Protein Databases –(UNIPROT, PIR, TREMBL), Protein family/domain databases (PROSITE, PRINTS, Pfam,), Metabolic & Pathway databases (KEGG), Structural databases (PDB).
Structural Bioinformatics: Classification of protein structures, Primary, Secondary and Tertiary structures, Quaternary structure, Protein folding concept, Potential energy map and Ramachandran plot. Secondary structure prediction methods, Classification of Three Dimensional Structures of Proteins, Motifs, Folds and Domains, Classification of Three Dimensional Structures in PDB (HSSP, SCOP, FSSP, CATH). Structural Alignment Methods, Homology Modeling, fold recognition and ab initio methods. Computer aided drug design (CADD), Molecular Docking.
Genomics: The Human Genome, Comparative Genomics (Comparative genomics of Model organisms), gene identification methods, primary gene expression analysis. Primary Sequence Analysis: Sequence alignment, Homology concept, pairwise sequence alignment, multiple sequence alignment, Phylogenetic Analysis, concept of SNP and snip analysis.
Books:
- Bioinformatics–Sequence, Structure and Databanks, Higgins, D., Taylor, W., Pub: Oxford University Press, Incorporated.
- Bioinformatics: A practical guide to the analysis of genes and proteins, Baxevanis, A. D., Ouellette, B.F.F., Pub: John Wiley and Sons Inc.
- Bioinformatics: Sequence and Genome Analysis, Mount, D.W., Pub: Cold Spring Harbor Laboratory Press.
- Structural Bioinformatics, Ed: Bourne, P. E., Weissig, H., Pub: Wiley-Blackwell.