Aniruddha Chatterjee | Department of Life Sciences

Profile

Aniruddha
Chatterjee
Rutherford Discovery Fellow (Royal Society of New Zealand)
Department of Life Sciences
School of Engineering (SoE)
Shiv Nadar University
Gautam Buddha Nagar Uttar Pradesh
India
Profile Summary 

Aniruddha Chatterjee is originally from Berhampore (West Bengal, India) where he completed his schooling. He moved to southern part of India and completed BSc (Osmania University, Hyderabad) and MSc degree (VIT University, Vellore) in Biotechnology with first class and distinction. Following this, Aniruddha came to the University of Otago in New Zealand in 2009, where he commenced his PhD and in his doctoral work, for the first time he mapped whole genome-scale DNA methylation patterns and variation in normal human neutrophil cells. Currently, he works in Dept. of Pathology at Otago and the main research interest of his lab lies in understanding driver epigenetic alterations in cancer metastasis and development of epigenetic biomarkers to predict patient response. Aniruddha already published 50 peer-reviewed articles and played a leading role in performing first reduced representation DNA methylation sequencing in human neutrophil, melanoma cancer cells and the model organism zebrafish. He also heavily published in the methodology development for DNA methylation and microRNA and gene expression analysis. Outside work, he enjoys dance/acting, sports, travelling and music. Aniruddha received several national and international awards for his work. In 2017, he was awarded one of the most prestigious fellowship in southern hemisphere, the Rutherford Discovery Fellowship from Royal Society of New Zealand. He is the founder of the Epigenetics User Group (EUG) in Otago and he substantially contributed in establishing a strong research programme in epigenetics and currently he is the head of the Epigenetics, Disease, and Phenotype Laboratory (EDP) at the University of Otago, New Zealand (URL: https://www.otago.ac.nz/chatterjee-lab/index.html)

Educational Qualifications 
2013
PhD (Pathology/ Epigenetics)
University of Otago, New Zealand
2008
M.Sc (Biotechnology)
VIT University, Vellore, India
2006
B.Sc (triple major: Biotechnology, Biochemistry, Chemistry)
Osmania University, Hyderabad, India
Work Experience 
10/18Present
Rutherford Discovery Fellow
Royal Society of New Zealand
I currently work here
02/18Present
Senior Research Fellow
Department of Pathology, Dunedin School of Medicine, University of Otago
Dunedin
I currently work here
01/19Present
Visiting Faculty
Shin Nadar University
Greater Noida, India
I currently work here
11/17Present
Associate investigator
Maurice Wilkins Centre CoRE
New Zealand
I currently work here
09/15Present
Affiliate investigator
Maurice Wilkins Centre CoRE
I currently work here
11/14
01/18
Research Fellow
Department of Pathology, Dunedin School of Medicine, University of Otago
Dunedin
Teaching & Research Interests: 

Chatterjee lab (see University of Otago URL: https://www.otago.ac.nz/chatterjee-lab/index.html) use bioinformatics and experimental approaches to study epigenetic changes in different cellular contexts to achieve a better understanding of the mechanism of disease in cancer. Our lab aim to use these discoveries to develop biomarkers for specific disease states.

We have four themes in our laboratory

  • Researching the origin and consequences of epigenetic alterations in cancer metastasis
  • Developing analytical tools for epigenomic analysis
  • Cellular and tissue specific epigenetics

Environmental epigenetics

Research Areas
Epigenetics, Cancer Biology, Genomics, Transcriptome, bioinformatics, CRISPR methylation

Awards(Selected): 

Fellowships and scholarships:

2017    Rutherford Discovery Fellowship, Royal Society, New Zealand
2016    Genesis Oncology Trust Professional Development award
2016    NZ-China Centre visiting Biomedical fellowship
2016    Wellcome Trust (UK) scholarship for advanced course in Genomics
2014    Fellowship to support salary: New Zealand Institute for Cancer Research
2014    JSPS and Royal Society of New Zealand visiting fellowship, Japan (one out of six recipients).
2013    Visiting fellow (short term): Genome Institute of Singapore (invited to work on DNA methylation sequencing).                  
2012    Travel Fellowship: Maurice Phyllis Paykel Trust, New Zealand.
2010    NRCGD trainee development fund award, New Zealand.                  
2009    Post-Graduate scholarship (PhD studies): National Research Centre for Growth and Development (NRCGD), New Zealand, value $110000, 3 years.
2009    Travel and exchange scholarship: Flanders institute of biotechnology, Belgium (among 11 selected candidate world- wide to present M.Sc thesis work and find PhD positions).

Awards and distinction:

2018   Ministry of Education (NZ): selected faculty for Global Conclave in India
2017    Best Collaboration award, Dunedin School of Medicine, Otago, NZ        
2015    illumina Emerging Researcher Award, New Zealand
2014     Best student publication award: Dunedin School of Medicine, University of Otago, New Zealand.
2013    Best poster prize: Illumina Asia Pacific Scientific summit, Phuket, Thailand.
2011 AGRF Young Investigator Award: Australian Epigenetic Alliance     meeting, Melbourne, Australia.
2004    Best Student Speaker: International Conference on Cybernatics, Systematics & Informatics, Hyderabad, India.

Academic excellence:

2004   Medal for ranking 1st in B.Sc Biotechnology at Osmania University, India (out of 4300 students).
2000     National scholarships for state rank (intermediate), Govt. of India.
2002     National scholarships for state rank (secondary), Govt. of India.
1993      National science talent awards (Indian Science Congress Association).
1994      National science talent awards (Indian Science Congress Association).

Scholarly Activity

Book

Aniruddha Chatterjee and Archana Pan “Genome and proteome composition of Bdellovibrio bacteriovorous” subtitle- Indications for recent horizontal gene transfer in Bdellovibrio bacteriovorous”. Lambert Academic publishing (LAP), Germany, ISBN: 978-3-8484-4989-7 (2012).URL:http://www.amazon.com/Genome-proteome-composition-Bdellovibrio-bacteriovorus/dp/3848449897

Book Chapters

Marjan Askarian-Amiri, Euan Roger, Aniruddha Chatterjee, Epigenetic in Melanoma: Graeme Finlay, Bruce Baguley, pp115-132, Springer, March 2018.

Journal Articles

Chatterjee A, Rodger EJ, Ahn A, Stockwell PA, Parry MP, Motwani J, Gallagher S, Shklovskaya E, Jessamy T, Eccles MR, Hersey P: Marked global DNA hypomethylation is associated with constitutive PD-L1 expression in melanoma, iScience (Cell Press). 2018 [IF= Due, Cell Press Flagship journal of high impact, national and international media highlights)]

Eccles MR, Chatterjee A, Rodger EJ: Identifying drivers of metastasis; towards a systematic approach, Translational Cancer Research. 7(6), October 2017. [IF= 1.2, Rank= Q2-Radiology, 123/287)]

Chatterjee A, Rodger EJ, Eccles MR: Epigenetics drivers of cancer metastasis. Seminars in cancer biology, August 2017 [IF= 9.96, Rank= Q1-Cancer research, 5/198)]

Macaulay E, Chatterjee A, Cheng X, Baguley BC, Eccles MR, Morison IM: The genes of life and death: a potential role for placental-specific genes in cancer. BioEssay. 39 (11), November, 2017 [IF= 4.73, Rank= Q1-Biochemisty, Genetics and Molecular Biology, 19/225)].

Ludgate JL, Wright J, Stockwell PA, Morison IM, Eccles MR, Chatterjee A: A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA. BMC Medical Genomics, 2017 [IF= 3.77, Rank= Q1-Genetics,77/310)].

Chatterjee A, Ahn A, Rodger EJ, Stockwell PA, Eccles MR: A bench             scientist’s guide for designing and analysing RNA-Seq data. Methods in Molecular Biology, May 2018 [IF=NA, Invited paper].

Ahn A, Chatterjee A, Eccles MR: The slow cycling phenotype: a growing problem for treatment resistance in melanoma. Molecular Cancer Therapeutics.16(6):1002-1009, June 2017 [IF=5.77, Rank= Q1-Oncology, 20/322].

Chatterjee A, Macaulay EC, Ahn A, Ludgate JL, Stockwell PA, Weeks RJ, Parry MF, Foster TJ, Knarston IM, Eccles MR, Morison IM: Comparative assessment of DNA methylation patterns between RRBS and Sequenom EpiTyper methylation analysis. Epigenomics. May, 2017 [IF=4.51, Rank= Q1-Genetics and Heredity, 31/166].

Rajendiran A, Chatterjee A, Pan A: Computational approaches and related tools to identify microRNAs in a species: A bird's eye view. Interdisciplinary Sciences: Computational Life Sciences (Springer), March 2017 [IF= 0.85, Rank= Q2-Health Informatics, 38/122)]

Rodger EJ and Chatterjee A: The epigenomic basis of common diseases. Clinical Epigenetics. 9(1). January 2017 [IF=4.33, Rank= Q1-Genetics, 46/310].

Leichter AL, Sullivan MJ, Eccles MR, Chatterjee A: MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours. Molecular Cancer. 16(1). January 2017  [IF=5.89, Rank= Q1-Oncology, 25/322).

Chatterjee A, Rodger EJ, Morison IM, Eccles MR, Stockwell PA: Tools and Strategies for analysis of genome-wide and gene-specific DNA methylation patterns. Methods in Molecular Biology, 2017. 1537: 249-277. [Invited paper]

Chatterjee A, Rodger EJ, Stockwell PA, Le Mée G, Morison IM:  Generating Multiple Base-resolution DNA Methylomes Using Reduced Representation Bisulfite Sequencing. Methods in Molecular Biology, 2017, 1537: 279-298 [Invited paper].

Chatterjee A, Stockwell PA, Ahn A, Rodger EJ, Leichter AL, Eccles MR: Genome-  wide methylation sequencing of paired primary and metastatic cell lines identifies  common DNA methylation changes and a role for EBF3 as a candidate epigenetic driver in melanoma metastasis. Oncotarget. December 2016 [IF=5.1, Rank= Q1-Oncology, 35/322, national and international media coverage for this paper].

Chatterjee A# Stockwell PA#, Stockwell PA, Rodger EJ, Parry MF, Eccles MR: scan_tcga tools for integrated epigenomic and transcriptomic analysis of tumour           subgroups. Epigenomics. September 2016. #equal contribution. [Cover story in Epigenie, IF=4.04, Rank= Q1-Genetics, 78/310].

Chatterjee A, Lagisz M, Rodger EJ, Zhen L, Stockwell PA, Duncan EJ, Horsfield JA, Jeykani J, Mathavan S, Ozaki Y, Nakagawa S: Sex differences in DNA methylation and       expression in zebrafish brain: a test of an extended ‘male sex driver’ hypothesis. Gene        (Elsevier) pii: S0378-1119 (16) 30437-1, May 2016. [Cover story in EpiBeat in Zymo,            USA, IF= 2. 3, Rank: Q2-Genetics, 151/310].

Jones A, Ferguson P, Gardner J, Rooker S , Sutton T , Ahn A, Chatterjee A,  Bickley V, Sarwar M , Emanuel P , Kenwright D , Shepherd P, Eccles MR: NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand. Oncotarget. May 2016. [IF=5.1, Rank= Q1-Oncology, 35/322, TV one and international media coverage for this paper].

Chatterjee A, Macaulay EC, Rodger EJ, Stockwell PA, Parry MF, Hester RE, Slatter TL, Hung NA, Devenish CJ, Morison IM: Placental hypomethylation is more pronounced in genomic loci devoid of retroelements: G3:Genes|Genomes|Genetics. 2016 Apr 29. pii:        g3.116.030379 [I.F=3.2, Rank: Q1-Medicine (miscellaneous), 182/1779].

Chatterjee A, Stockwell PA, Rodger EJ, Morison IM: Genome-scale DNA methylome and transcriptome profiling of human neutrophils. Scientific Data. 2016, 3: 160019 [IF=4.82, Nature publishing journal, highly accessed paper].

Leichter AL, Purcell RV, Sullivan MJ, Eccles MR, Chatterjee A: Multi-platform microRNA profiling of hepatoblastoma patients using formalin fixed paraffin embedded archival samples. GigaScience. 2015, 4:54 [IF=7.46, Rank: Q1- Genetics, in top 5%].

Chatterjee A, Stockwell PA, Rodger EJ, Duncan EJ, Parry MF, Weeks RJ, Morison IM: Genome-wide DNA methylation map of healthy individuals widespread inter-individiual epigenetic variation. Scientific Reports. 2015, 11:17328. [IF=5.6, Q1-Multidisiplinary science, 4/109, Cover story in Epigenie, highly accessed]

Chatterjee A, Eccles MR: DNA methylation and epigenomics: new technologies and emerging concepts. Genome Biology 2015, 16:103. [IF=11.3, Rank= Q1-Genetics,        8/310, permanently flagged as highly accessed paper by Genome Biology].

Chatterjee A, Leichter AL, Fan V, Tsai P, Sullivan M, Purcell R, Eccles MR: A cross comparison of technologies for the detection of microRNAs
in clinical FFPE samples of hepatoblastoma patients. Scientific Reports 2015, 5:10438. [Highly accessed, IF=5.6, Q1-Multidisiplinary science, 4/109]

Chatterjee A, Stockwell PA, Horsfield JA, Morison IM, Nakagawa S: Base-   resolution DNA methylation landscape of zebrafish brain and liver. Genomics Data 2014, 2:342-344. [IF=Due, Rank: Q3-Biotechnology, 184/270].

Rodger EJ, Chatterjee A, Morison IM: 5-hydroxymethylcytosine: a Potential Therapeutic Target in Cancer. Epigenomics 2014, 5:503-514. [IF=4.04, Rank= Q1-Genetics, 78/310].

Stockwell PA#, Chatterjee A#, Rodger EJ, Morison IM: DMAP: differential   methylation analysis package for RRBS and WGBS data. Bioinformatics 2014,   30:1814-1822.#equal contribution. [IF=5.77, Rank: Q1-Statistics and Probability and also in Biochemistry, 5/179 and 13/396, Cover story in Epigenie]

Chatterjee A, Ozaki Y, Stockwell PA, Horsfield JA, Morison IM, Nakagawa S: Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing. Epigenetics 2013, 8:979-989. [IF=4.7, Rank: Q1-Cancer Research, 23/198,             Cover story in Epigenie, best publication award from Dunedin School of Medicine].

Laskar A, Chatterjee A, Chatterjee S, Rodger EJ: Three-Dimensional Molecular Modeling of a Diverse Range of SC Clan Serine Proteases. Molecular Biology International 2012, 2012:580965. . [IF=due]

Chatterjee A: Conference Scene: Epigenetic regulation: from mechanism to    intervention. Epigenomics 2012, 4:487-490. [IF=4.04, Rank= Q1-Genetics, 78/310].

Chatterjee A#, Rodger EJ#, Stockwell PA, Weeks RJ, Morison IM: Technical considerations for reduced representation bisulfite sequencing with multiplexed             libraries.Journal Of Biomedicine & Biotechnology 2012, 2012:741542. # equal contribution [IF=3.2, Rank: Q2-Biochemistry, Genetics and Molecular Biology, 70/219,            Key technical article in Epigenie, Customer success story by Agilent]..

Laskar A, Rodger EJ, Chatterjee A, Mandal C: Modeling and structural analysis of PA clan serine proteases. BMC Research Notes 2012, 5:256. [IF=Due, Rank: Q2- Biochemistry, Genetics and Molecular Biology, 74/219].

Chatterjee A, Stockwell PA, Rodger EJ, Morison IM: Comparison of alignment software for genome-wide bisulphite sequence data. Nucleic Acids Research 2012,        40:e79. [IF=10.2, Rank= Q1-Genetics, 12/310, Editors choice article –Genome web,             February 2012. Most read article March, May 2012, NAR].

Chatterjee A, Morison IM: Monozygotic twins: genes are not the destiny? Bioinformation 2011, 7:369-370. [IF=0.80, Rank= 80 out of 207 in Biochemistry,       Genetics and Molecular Biology]

Laskar A, Rodger EJ, Chatterjee A, Mandal C: Modeling and structural analysis of evolutionarily diverse S8 family serine proteases. Bioinformation 2011, 7:239-245. [IF=0.80, Rank= 80 out of 207 in Biochemistry, Genetics and Molecular Biology]

Pubmed non-indexed:
Chatterjee A, Basu A:  Rubisco: Limitations and re-engineering for a better    enzyme. International Research Journal of Plant Science 2011, 2(2):022-024. [Downloaded more than 1000 times: source Research Gate].

Chatterjee A, Pan A: Horizontal Gene Transfer-a Genomic Perspective. Online Journal of BioTechnology Research 2010, 1(4): 167-169.

Laskar A, Mandal CN, Chatterjee A: Protease-Inhibitor Interactions – A structural Insight. International Journal of Biotechnology & Biochemistry 2010, 6(2):231-258.

Basu A, Chatterjee A, Kottalil MD: Helicobacter pylori: revisiting the role of host        genetics in susceptibility to infectious diseases. Journal of Computational intelligence and Bioinformatics 2010, 1(3): 1-9.

Laskar A, Chatterjee A: Protease – Revisiting the Types and Potential. Online Journal of Biotechnology Research 2009,1(1): 55-61.

Laskar A, Chatterjee A: Computer aided Molecular Modelling and its implications. Bioinformatics Trends 2009,1(4): 85-92.

Chatterjee, A: St. John’s Wort (Hypericum perforatum): A Review on   Pharmacodynamics and Therapeutic Potential. Herbal Tech Industry 2009, 5(5):18-  22. [Appeared in Journal Cover]

Chatterjee A: Bdellovibrio bacteriovorus: Life cycle and potential as a predatory renaissance. Advanced Biotech 2009, VIII (09):27-29. [Appeared in Journal Cover].

Shrivastava R, Sarkar R, Chatterjee A, Khadikar PV: QSAR Studies on the Action of an Algicide from a Cyanobacterium: Oscillatoria laetevirens, on Photosystem II Activity. Advanced Biotech 2009, VIII (09):15-18.

Shrivastava R, Chauhan KU, Sarkar R, Chatterjee A: Observation On The Reaction Rate Kinetics In Cellulosic Paper Waste. Advanced Biotech 2009, VIII          (07):21-25.

Chatterjee A, Sarkar R: RNA Interference (RNA i): A novel strategy in health care and crop improvement. Advanced Biotech 2008, VII (3):36-38. [Appeared in Journal Cover].

Conference Publications

Roy R, Chatterjee A, Sarkar ND, & Roy B: Genome wide study reveal microrna based methylation phenotype in oral cancer. Cancer Research 2017, 13: 1484-1484. [IF=9.33, Rank= Q1-Oncology, 9/344]

Rodger E, Chatterjee A, Stockwell, P, & Morison I: Developing a blood-based diagnostic test for myedysplastic syndrome. Leukemia Research 2015, 39:S31-S32. [IF=2.35, Rank= Q2-Hematology, 39/123]

Rodger E, Chatterjee A, Stockwell, P, & Morison I: DNA methylation markers of myedysplastic syndrome. New Zealand Medical Journal 2014, 127(1398). [IF=NA, Rank= Q3-Medicine]

Eccles MR, Motwani J, Chatterjee, A: Investigation of the relationship between MITF and POU3F2 expression and the notion of a "genetic switch" underlying phenotype switching in melanoma. Journal of Clinical oncology Oncol 32, 2014 (suppl; abstr e22081) [IF=20.98, Rank= Q1-Oncology, 5/322].