Deepak Sehgal | Department of Life Sciences

Profile

Deepak
Sehgal
Professor and Head
Department of Life Sciences
School of Natural Sciences (SoNS)
A321G
Block-Shiv Nadar University, Shiv Nadar University
Greater Noida Uttar Pradesh
India
Extn: 
807
Profile Summary 

Professor Sehgal started his scientific career by studying Masters in Animal Genetics and Breeding from National Dairy Research Institute, Karnal where he developed a method to predict the quality attributes of dairy animals by observing sex chromatin.

He pursued M.Phil. in Molecular Biology at university of Poona whereby he demonstrated that in chicken, the messages for eye lens crystalline were present as early as the gastrula stage. After that Dr. Sehgal moved to do his Doctorate in Biochemistry from Indian Agricultural Research Institute, New Delhi where he identified the gene, for neurotoxin synthesis, in wild pea which is responsible for lower limb paralysis. For his Post doctorate, Dr. Sehgal joined University of Maryland, USA where he worked on protein purification. 

His second Post Doctorate was at Indian Institute of Science, Bangalore whereby his major accomplishment was to show that caterpillar Bombay mori could be used as Bioreactors for protein synthesis. Further, he was appointed as a Senior Research Scientist in department of Virology at International Centre for Genetic Engineering and Biotechnology, New Delhi. He worked on various aspects of HEV and also found a putative drug combination to reduce genomic load of Hepatitis B virus. He received Welcome Research grant and worked on Drosophila Expression System at University of Sussex (UK).

Professor Sehgal joined Invitrogen (USA) as a group Leader of Protein expression and purification. Subsequently, he joined PanaceaBiotec Ltd. a Biopharmaceutical company where he was group leader and Projects coordinator to develop anti cancer drugs.

He coached the M.Sc. trainees in Molecular Biology to clone various genes into in house designed vectors. Professor Sehgal has a great passion for the innovative research and aptitude for teaching.

Educational Qualifications 
1991
Ph.D. (Plant Biochemistry)
Indian Agricultura Institute
1986
M.Phil.
University of Poona (Molecular Biology)
1983
M.Sc. (Genetics and Breeding)
National Dairy Researh Institute, Karnal
Work Experience 
19992006
Senior Research Scientist
International Center for Genetic Engineering and Biotechnology
New Delhi
20062008
Group Leader
Invitrogen Bioservices
Bangalore
20082012
Group Leader (Biosimilars)
Panacea Biotec Ltd.
New Delhi
06/12Present
Professor and Head of Department, Life Sciences
Shiv Nadar University
SNU
I currently work here
Teaching & Research Interests: 

RESEARCH AREAS

Virology: Hepatitis E Virus Culture system and development of the Animal model System

Protein Chemistry: Study the protein processing, structural analysis and their role in replication of HEV.

Drug Development: Biophysical structural analysis of the HEV proteins, Virtual screening and Wet lab validation of the inhibitors as the putative drug candidate

Awards(Selected): 
2004

 Wellcome Trust Fellowship.

2004

Recipient of Department of Biotechnology (DBT) award.

2005

Member, Evaluation committee for Central Silk Board, Mysore 

2015

Expert Reviewer BIRAC, DBT

Scholarly Activity

Journal Publications (accepted or published)

2009

Manjula Kalia,* Vivek Chandra, Sheikh Abdul Rahman, Deepak Sehgal and Shahid Jameel (2009) Heparan Sulfate Proteoglycans Are Required for Cellular Binding of the Hepatitis E Virus ORF2 Capsid Protein and for Viral Infection. JOURNAL OF VIRO. (24):1271424.

2003

Zafrullah, M., Khursheed, Z., Yadav, S., Sehgal, D., Jameel., S and Ahmad, F. (2003) Acidic pH enhances structure and structural stability of the capsid protein of hepatitis E virus. Biochem. Biophys. Res. Commun. 313: 67-73.

2003

Sehgal, D., Malik, P. S. and Jameel, S. (2003) Purification and diagnostic utility of the hepatitis E virus capsid protein expressed in insect larvae. Protein Expr. Purif. 27: 27-34.

2001

Korkaya, H., Jameel, S., Gupta, D., Tyagi, S., Kumar, R., Zafarullah, M.,Mazumdar,M., Lal, S.K., Xiafong, L., Sehgal, D., Das, S.R., and Sahal, D. (2001) The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. J. Biol. Chem. 9: 42389-400.

2006

Sehgal D, Thomas S, Chakraborty M, Jameel S. Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein. Virol J. 2006 May 26;3:38

2006

Parvez MK, Sehgal D, Sarin SK, Basir SF, Jameel S. Inhibition of hepatitis B virusDNA replicative intermediate forms by recombinant interferon-gamma. World J Gastroenterol. 2006 May 21;12(19):3006-14.

1998

Sehgal, D and K.P.Gopinathan (1998) Over-expression of Green fluorescent protein in Bombyx mori using baculovirus expression vector system. Biotechniques 25: 997-1007.

2001

Acharya,A., Sriram,S., Sehrawat,S., Rahman,M., Sehgal, D and Gopinathan,K.P. (2001) Bombyx mori nucleopolyhedrovirus: molecular biology and biotechnological applications for large-scale synthesis of recombinant proteins. Curr. Sci. 83: 4555-465.

1994

Sehgal, D and Vijay, I.K. (1994) A method for the high efficiency of water- soluble Carbodiimide-mediated amidation. Analytical Biochemistry 218: 87-91.

1992

Sehgal, D., Santha, I.M. and S.L. Mehta (1992) Purification of Oxalyl CoA Synthetase enzyme from Lathyrus sativus and raising of antibodies. J. Pl. Biochem.Biotech. 1: 97-100.

2016

Gunjan Mishra, Vivek Ananth, Kalpesh Shelke, Deepak Sehgal, Jayaraman Valadi. Classification of the Anti-Hepatitis Peptides using Hybrid-Ant Colony-Infogain Based Support Vector Machine”. Bioinformation 12(1): 012-014 (2016). Link: http://www.ncbi.nlm.nih.gov/pubmed/27212838

2014

Gunjan Mishra, Vivek Ananth, Kalpesh Shelke, Deepak Sehgal, Jayaraman Valadi. Hybrid-ACO Chaos assisted Support Vector Machines for classification of Medical Datasets.” Published in Advances in Intelligent And Soft Computing (AISC) Series of Springer as SocProS 2014 Conference Proceedings. Link: http://link.springer.com/chapter/10.1007/978-81-322-2220-0_8#page-1 

2017

Mishra, Gunjan, Deepak Sehgal, and Jayaraman K. Valadi. “Quantitative Structure Activity Relationship study of the Anti-Hepatitis Peptides employing Random Forests and Extra-trees regressors”. Bioinformation 13.3(2017): 6

2017

Yash Shah, Deepak Sehgal and  Jayaraman K Valadi  "Recent Trends in Prediction of Antimicrobial Peptides employing Machine Learning Techniques” (2017 Bioinformation Volume 13(12); 413-417.

Projects

 

2008

HUPO Grant on “locus for hereditary hypotrichosis localized to human chromosome18”
Value -  $120,000​
Company - Invitrogen​
Submission - June 2008​

2008

HUPO grant on “expression of Gold standard markers using Mass spectroscopy”
Value - $ 60,000​
Company - Invitrogen​
Submission - June 2008​

Generation of Baculovirus vector with GST- tag
Value- $ 30,000​
Company - Invitrogen​
Submission - Dec. 2007​

2011

Generation of stable clone for Darbepoetin an erythropoietin analogue
Value: Company support​
Company: Panacea Biotec​
Submission: Nov. 2011​

2012

Development of MAb Etanercept an erythropoietin analogue
Value: Company support​
Company: Panacea Biotec​
Submission: Jan. 2012[DS1]​

Development of Insects as Bioreactors for protein synthesis
Value: 35 Lakhs​
Funding Agency: DBT​
Submission: December, 2005​

Setting up a functional expression system using Drosophila S-2 cells that express Shack-M drosophila gap junctional protein and ORF, a hepatitis E Virus protein
Value: £ 12064
Funding Agency: Wellcome Trust
Submission: September, 2003

Development Of An In Vitro System For Hev Propagation To Study Polyprotein Processing And Experimental Infection In Murine Model
Amount: 48 Lakhs​
Role: Principal Investigator​
Funding Agency: DST​
Status: Approved​

Structural Characterization And Inhibitor Development For HEV-Methyltransferase
Amount: 56 Lakhs​
Role: Principal Investigator​
Funding Agency: DBT​
Status: Approved​

Identification Of Hepatitis E Virus Replication Inhibitors From A Hepatoprotective Medicinal Herb, Picorhiza  Kurroa
Amount: 48 Lakhs​
Role: Principal Investigator​
Funding Agency: ICMR​
Status: Proposed​