Dr. Koyeli Mapa | Department of Life Sciences

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Dr. Koyeli
Mapa
Associate Professor
Department of Life Sciences
School of Natural Sciences (SNS)
koyeli.mapa@snu.edu.in
214
Block-R, Shiv Nadar University
Dadri Uttar Pradesh
India
91-0120-7170100
Extn: 
138
Profile Summary 

Koyeli obtained an MBBS from Calcutta Medical College following which she moved from medicine to basic research. After a brief stint at the Indian Institute of Science (IISc), Bangalore, she moved to Germany for her doctoral studies. Subsequently, she graduated with “summa cum laude” from the Medical faculty of Munich University (LMU), Germany, as a fellow of the prestigious International Max Planck Research School (IMPRS). Back in India, she received the Innovative Young Biotechnologist Award (IYBA) from the Department of Biotechnology, Government of India and worked as an IYBA fellow in the CSIR-Institute of Genomics and Integrative Biology, Delhi, before joining Shiv Nadar University. Koyeli is interested in delineating the role of molecular chaperones in heath and misfolding-induced diseases such as neurodegenerative disorders. Simultaneously, she is interested in deciphering the stress response pathways of mitochondria, the cellular power-house and how mitochondrial dysfunction happens during various pathological conditions. Koyeli has published several research papers in various journals of high international repute.

Educational Qualifications 
2009
Ph.D. in Biochemistry
Ludwig Maximilian University, Munich
2002
MBBS
Calcutta Medical College, University of Calcutta
Work Experience 
07/20 – Present
Associate Professor,
Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi-NCR
I currently work here
2015 – 2020
Assistant Professor,
Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Delhi-NCR
I currently work here
2010 – 2015
IYBA Fellow,
CSIR-IGIB,
Delhi
2005 – 2009
Doctoral student (IMPRS graduate school),
Institute of Physiological chemistry, LMU, Munich,
Munich, Germany
I currently work here
2004 – 2005
IMPRS Fellow,
Technical University Dresden, Germany,
Dresden, Germany
2002 – 2003
JRF,
IISc, Bangalore,
Bangalore
2001 – 2002
Medical Intern,
Calcutta Medical College and Hospital,
Calcutta
Teaching & Research Interests: 

Research Interests

Protein homeostasis, molecular chaperones, cellular stress response pathways, mitochondrial biogenesis

Teaching interests

Animal physiology, Biology of Infectious diseases, Recombinant DNA technology

Conferences (Select): 
  1. Invited lecture in International webinar on  Cellular and Protein Homeostasis Webinar Series, titled  "Deciphering the sub-mitochondrial compartment specific proteotoxic stress response using S. cerevisiae as a model organism" on February 16, 2021.
  2. Invited lecture in a webinar organized by Sharda University, School of Basic Sciences and Research, Department of Chemistry and Biochemistry, titled “An overview of role of protein quality control machineries in maintaining cellular proteostasis” on May 29th, 2020.
  3. Invited lecture at Department of Biology, Ashoka University, Sonepat, in an in-house symposium held on 22nd February 2020. Title of the talk was “Unravelling sub-compartment specific mitochondrial misfolding stress response”.
  4. Invited lecture titled “Mitochondrial protein homeostasis: Why is it important and what are the master regulators of it?” at Biophysica, a symposium on Biophysics held at Jamia Milia Islamia organized by Centre for interdisciplinary research in basic sciences, on 20th November, 2018.
  5. Invited lecture at CSIR-IGIB in Protein folding meeting held on 24th March 2018 titled “Regulation of protein homeostasis”.
  6. Invited lecture at RTCMBR at SNU titled “Deciphering the sub-compartment specific mitochondrial unfolded protein response” on 28th, October 2017.
  7. Invited lecture at inStem/NCBS titled “Deciphering the Protein Quality control pathways and inter-compartment communication during misfolding stress” on 8th November 2016.
  8. Invited lecture titled "Study of chaperone-substrate interactions using single molecule FRET" in the International conference on "Recent Advances in Molecular Spectroscopy: Fundamentals and Applications in Materials and Biology (RAMS-2016)" held at School of Chemistry, University of Hyderabad, Hyderabad, India,  during March 2–4, 2016

 

Awards(Selected): 
2020

Joined Board of Reviewing Editors (BRE) of the journal eLife in the area of Biochemistry and Chemical Biology

https://elifesciences.org/about/people/biochemistry-chemical-biology

2009

Innovative Young Biotechnologist Award (IYBA) from DBT, India

2005

Fellowship from International Max Planck Research School (IMPRS), Munich, Germany for pursuing graduate research

2004

Fellowship from International Max Planck Research School (IMPRS), Dresden, Germany for pursuing graduate research

Scholarly Activity

Research Publications in peer-Reviewed International Journals

1. Alterations in inter-organelle crosstalk and Ca2+ signaling through mitochondria during proteotoxic stresses. Ali M, Boosi Narayana Rao K, Majumder P, Sarkar R, Mapa K * (*corresponding author). Mitochondrion. 2021 Mar;57:37-46. Impact factor: 3.99

2. GROEL/ES Buffers Entropic Traps in Folding Pathway during Evolution of a Model Substrate. Sadat A, Tiwari S, Verma K, Ray A, Ali M, Upadhyay V, Singh A, Chaphalkar A, Ghosh A, Chakraborty R, Chakraborty K, Mapa K * (*corresponding author). J Mol Biol. 2020 Aug 21. S0022-2836(20)30509-X. doi: 10.1016/j.jmb.2020.08.015. Online ahead of print. PMID: 32835659 Impact factor: 5.04

3. Inter-domain communication suppressing high intrinsic ATPase activity of Sse1 is essential for its co-dissaggregase activity with Ssa1. Kumar V, Peter JJ, Sagar A, Ray A, Jha MJ, Rebeaud ME, Tiwari S, Goloubinoff P, Ashish* and Mapa K* (*corresponding author). FEBS Journal 2020 Feb;287(4):671-694. Impact factor: 4.75

4. Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks. Ghosh A, Gangadharan A, Verma M, Das S, Matai L, Dash DP, Dash D*, Mapa K*, Chakraborty K*. Cell Mol Life Sci. (*equally contributing senior author) 2019 Apr;76(8):1605-1621.Impact factor: 6.7

5. Monitoring conformational heterogeneity of DnaK lid domain during its functional chaperone cycle.Banerjee R, Jayaraj GG, Peter J, Kumar V, Mapa K*. (*corresponding author). FEBS Journal 2016 Aug;283(15):2853-68. . Impact factor: 4.5

6. Banerjee R, Gladkova C, Mapa K, Witte G, Mokranjac D. Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein. Elife. 2015 Dec 29;4. pii: e11897. doi: 10.7554/eLife.11897. Impact factor: 9.32

7. Nagpal S, Tiwari S, Mapa K*, Thukral L*. Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding. PLoS Comput Biol. 2015 Sep 22;11(9):e1004496.   (* joint corresponding authors). Impact factor: 4.62

8. Kumar S, Mapa K, Maiti S. Understanding the effect of LNA and 2´-O methyl modification on the hybridization thermodynamics of miRNA-mRNA pair in the presence and absence of AfPiwi protein. Biochemistry. 2014 Feb 24.  Impact factor: 3.42

9. Sikor M, Mapa K, Voith von Voithenberg L, Mokranjac D, and Lamb DC. Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET. EMBO J. 2013 Apr 26. (2013) 32, 1639 - 1649. Impact factor: 10.0

10. Agarwala P, Pandey S, Mapa K, Maiti S. G-quadruplex augments translation in 5' Untranslated Region of Transforming Growth Factor β2 (TGFβ2). Biochemistry. 2013 Mar 5;52(9):1528-38. Impact factor: 3.42

11. Tiwari S, Kumar V, Jayaraj GG, Maiti S, Mapa K*. Unique Structural Modulation of a Non-Native Substrate by Cochaperone DnaJ. Biochemistry. 2013 Feb 12;52(6):1011-8.  (*corresponding author). Impact factor: 3.42

12. Mapa K*, Tiwari S, Kumar V, Jayaraj GG and Maiti S. Information encoded in non-native states drives substrate-chaperone pairing. Structure 2012 Sep 5;20(9):1562-73. (*corresponding author). Impact factor: 6.33

13. Kumar S, Bose D, Suryawanshi H, Sabharwal H, Mapa K, Maiti S. Specificity of RSG-1.2 peptide binding to RRE-IIB RNA element of HIV-1 over Rev peptide is mainly enthalpic in origin. PLoS One. 2011;6(8):e23300. Epub 2011 Aug 10. Impact factor: 4.0

14. Popov-Celeketic D, Waegemann K, Mapa K, Neupert W and Mokranjac D. Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex.EMBO Rep. 2011 Jun;12(6):542-8. Impact factor: 7.8

15. Mapa K, Sikor M, Kudryavstev V, Waegemann K, Kalinin S, Seidel CAM, Neupert W, Lamb DC and Mokranjac D.The Conformational dynamics of the mitochondrial Hsp70 chaperone. Mol Cell. 2010 Apr 9;38(1):89-100. Impact factor: 13.5

16. Blamowska M, Sichting M, Mapa K, Mokranjac D,Neupert W and Hell K. ATPase Domain and Interdomain Linker Play a Key Role in Aggregation of Mitochondrial Hsp70 Chaperone Ssc1. J Biol Chem. 2010 Feb 12;285(7):4423-31. Impact factor: 5.5

17. Mokranjac D, Sichting M, Popov-Celeketic D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W. Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria. Mol Biol Cell. 2009 Mar; 20(5):1400-7. Impact factor: 5.5

18. Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic DA, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D. Interaction of tim23 with tim50 is essential for protein translocation by the mitochondrial tim23 complex. J Biol Chem. 2009 Feb 20;284(8):4865-72. Impact factor: 5.5

19. Popov-Celeketić D*, Mapa K*, Neupert W, Mokranjac D.Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria. EMBO J. 2008 May 21;27(10):1469-80. (*Equally contributing first authors). Impact factor: 8.0

20. Dhar D*, Mapa K.*, Pudi R., Srinivasan P., Bodhinathan K., Das S. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. Arch Virol. 2006Mar;151(3) :509-24. (*Equally contributing first authors). Impact factor: 1.8

21. Bhattacharyya S., Mapa K., Prabhavathi S., Sudhamani SR., Menon PK., John KP. ,Shivaram C., Amarnath S., Das S. Phylogenetic conservation of the stem-loop III structure of the 5' untranslated region of Hepatitis C virus RNA among natural variants in samples collected from Southern India. Arch Virol. 2004 May; 149(5): 1015-26. Impact factor: 1.8

 

Invited Book Chapters

1. Hsp70: a multi-tasking chaperone at the crossroad of cellular proteostasis. Vignesh Kumar and *Koyeli Mapa#. (# Primary and corresponding author).  Regulation of Heat Shock Protein Responses, 251-274. Edited by Prof. Alexzander A. A. Asea and Dr. Punit Kaur, Springer, Heat Shock Protein Series (13). 2018.

2. Possible Therapeutic Intervention Strategies For COVID-19 By Manipulating The Cellular Proteostasis Network. Mudassar Ali#, Jyotirmoy Rajukar#, Priyanka Majumder, Mainak Pratim Jha, Rajasri Sarkar, and Koyeli Mapa* (* corresponding author). (Accepted in Springer Nature Book on Coronavirus Therapeutics – Volume I - Basic Science and Therapy Development)

3. An Overview of Protein Homeostasis Pathways that Safeguard the Cellular Powerhouse from Proteotoxic Stresses. Priyanka Majumder, Mudassar Ali, Rajasri Sarkar, and Koyeli Mapa* (* corresponding author). (Accepted in Springer Nature Book on Heat Shock Protein Series)

Ongoing Extramural Projects

 

1. SERB Core Research Grant (CRG)

Project Title: “Elucidation of role of cytosolic chaperone Sse1, Hsp110 of yeast, during ER stress”

PI: Dr. Koyeli Mapa
Amount Sanctioned: Rs 43,80,663
Duration: 36 months (2020-2023)

2. DBT project under Basic Research in Modern Biology scheme

Project Title: “A systemic investigation on sub-compartment specific proteotoxicity in mitochondria and the adaptive response mechanisms”
PI: Dr. Koyeli Mapa (SNU) and Dr. Swasti Raychaudhuri (CSIR-CCMB)
Amount Sanctioned: Rs 84,77,670

Duration: 36 months (2019-2022)

 

Ongoing Student Grants

1. ICMR- Senior Research Fellowship grant to Ms Rajasri Sarkar

Project Title: “Elucidating the role of TOM complex subunits as potential regulators of Sub-compartment Specific unfolded protein response in mitochondria”
PI: Rajasri Sarkar (SRF) and Dr. Koyeli Mapa (guide)

Amount Sanctioned (in INR): Rs 13,20,000
Duration: 36 months (2019-2022)

2. ICMR- Senior Research Fellowship grant to Mr. Mainak Pratim Jha

Project Title: “Understanding the non-canonical role of yeast cytosolic Hsp110 molecular chaperone during endoplasmic reticulum stress”
PI: Mainak Pratim Jha (SRF) and Dr. Koyeli Mapa (guide)

Amount Sanctioned (in INR): Rs 13,20,000
Duration: 36 months (2021-2024)

 

Completed Extramural Projects

1. SERB Young Scientist Grant

Project Title: “Delineation of conformational allostery of Hsp110 molecular chaperones”

PI: Dr. Koyeli Mapa
Amount Sanctioned: Rs 29,36,000
Duration: 36 months (2015-2018)

2. DBT project under Innovative Young Biotechnologist Award (IYBA)

Project Title: “Intracellular protein conformational dynamics”
PI: Dr. Koyeli Mapa (SNU)
Amount Sanctioned: Rs 72,00,000

Duration: 36 months (2010-2015)