Dr. Rajan Vyas | Department of Life Sciences

Profile

Dr. Rajan
Vyas
Assistant Professor
Department of Life Sciences
School of Natural Sciences (SNS)
321 M
Block-A, Shiv Nadar University
Gautam Budha Nagar Uttar Pradesh
India
Extn: 
280
Educational Qualifications 
Ph.D.
Department of Biotechnology, Panjab University, Chandigarh.
Work Experience 
09/10
03/12
National Institute of Immunology,
Postdoctoral Fellow ,
New Delhi
04/12
12/14
The Ohio State University, Columbus, Ohio,
Postdoctoral Fellow ,
US
01/15
03/17
Case Western Reserve University, Cleveland, Ohio,
Postdoctoral Fellow ,
US
03/18
02/20
Central University of Punjab, Bathinda,
Ramalingaswami Fellow (Assistant Professor) ,
Punjab
Teaching & Research Interests: 

Structure based drug designing using Protein X-ray crystallography.

Awards(Selected): 
20182023

Selected as Ramalingaswami Re-entry Fellow (2018-2023) by Department of Biotechnology, India.

2007

Availed “Deutscher Akademischer Austausch Dienst" (DAAD) fellowship (June 1 - November 30, 2007) sponsored by German Academic Exchange Service to work in European Molecular Biology Laboratory (EMBL-Hamburg), Germany.

Scholarly Activity

Journal Publications (accepted or published)

2019

Bhavya Jha*, Rajan Vyas*, Jaya Bhushan, Devinder Sehgal and Bichitra Kumar Biswal (2019). Structural insights into substrate specificity of SP_0149, the substrate binding protein of a methionine ABC transporter from Streptococcus pneumonia. Acta Crystallogr. Section F75, 520-528. Impact Factor:1.199 (* equal author).

2018

Soumili Chatterjee, Rajan Vyas, Sreevatsa Chalamalasetti, Indra Sahu, Jérôme Clatot, Xiaoping Wan, Gary Lorigan, Isabelle Deschênes, and Sudha Chakrapani, (2018). The Voltage-Gated Sodium Channel Pore exhibits Conformational Flexibility during Slow Inactivation. Journal of General Physiology, 150(9):1333-1347. Impact Factor: 4.788.

2017

Rajan Vyas, Andrew J. Reed, Austin T. Raper, Walter J. Zahurancik, Petra C. Wallenmeyer and Zucai Suo. (2017). Structural basis for the D-stereoselectivity of human DNA polymerase β. Nucleic Acid Research, 45(10):6228-6237. Impact Factor: 10.162.

2017

Reed, Andrew*; Vyas, Rajan*; Raper, Austin and Suo, Zucai (2017). Structural Insights into the Post-Chemistry Steps of Nucleotide Incorporation Catalyzed by a DNA Polymerase. Journal of the American Chemical Society (JACS). 139 (1), 465–471 (* - equal author). Impact Factor:13.858.

2016

Xing Guo, XiaoYan Sun, Di Hu, Ya-Juan Wang, Hisashi Fujioka, Rajan Vyas, Sudha Chakrapani, Amit Umesh Joshi, Yu Luo, Daria Mochly-Rosen and Xin Qi. (2016). VCP recruitment to mitochondria by mutant Huntingtin causes mitophagy impairment and neurodegeneration in models of Huntington's disease. Nature Communication. 7:12646; 1-17. Impact Factor:12.124.

2016

Nazia Nasir, Avishek Anant, Rajan Vyas, Bichitra Kumar Biswal. (2016). Crystal structures of Mycobacterium tuberculosis HspAT and ArAT reveal structural basis of their distinct substrate specificities. Sci Rep., 6: 18880; 1-13. Impact Factor:4.259

2015

Vyas, R., Efthimiopoulos, G., Tokarsky, E.J., Malik, C.K., Basu, A.K., and Suo, Z. (2015). Mechanistic Basis for the Bypass of a Bulky DNA Adduct Catalyzed by a Y-Family DNA polymerase. Journal of American Chemical Society (JACS). 137 (37), 12131-12142. (Highlighted in F1000Prime), Impact Factor:13.858

2014

Gaur, Vineet, Vyas, R, Fowler, Jason; Efthimiopoulos, G; Feng, J, Suo, Z (2014), Structural and Kinetic Insights into Binding and Incorporation of L-Nucleotide Analogs by a Y-family DNA Polymerase. Nucleic Acid Research, 42(15):9984-95. Impact Factor:10.162

2014

Vyas, R., Walter J. Z., Zucai Suo (2014). Structural Basis for the Binding and Incorporation of Nucleotide Analogs with L-Stereochemistry by Human DNA Polymerase λ. Proc Natl Acad Sci USA.; 111(30): E3033-42. Impact Factor:9.661

2013

Nazia Nasir, Rajan Vyas and Bichitra K Biswal (2013). Sample preparation, crystallization, and structure solution of HisC from Mycobacterium tuberculosis. Acta Crystallogr. F69 (4):445-448. Impact Factor:0.799

2012

Vyas, R., Rupinder Tewari, Manfred Weiss and Subramanian Karthikeyan (2012). Structures of ternary complexes of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37Rv. Acta Crystallogr. D68 (6), 671-679. Impact Factor:2.114

2012

Nazia Nasir, Rajan Vyas, Chetna Chugh, Mohammad Syed Ahangar and Bichitra Biswal (2012). Molecular cloning, Over-expression, Purification, Crystallization, and Preliminary X-ray Diffraction Studies of Histidinol Phosphate Aminotransferase (HisC2) from Mycobacterium tuberculosis, Acta Crystallogr. F68 (1), 32-36. Impact Factor:0.799

2011

Mohammad Syed Ahangar, Yogesh Khandokar, Nazia Nasir, Rajan Vyas and Bichitra Biswal (2011). HisB from Mycobacterium tuberculosis: Cloning, Over-expression in Mycobacterium smegmatis, Purification, Crystallization, and Preliminary X-ray Crystallographic Analysis, Acta Crystallogr. F67 (11), 1451-1456. Impact Factor:0.799

2011

Bhushan. J., Vyas. R, Sharma. T, Sehgal. D. and Biswal. B.K. (2011).  “Cloning, Over-expression, Purification, Crystallization, and Preliminary X-ray Studies of SP_0149, the Substrate Binding Protein of an ABC Transporter from Streptococcus pneumoniae. Acta Crystallogr. F67 (7), 797-799. Impact Factor:0.799

2011

Gautam, A., Vyas, R., Tewari. R. (2011). Peptidoglycan Biosynthesis Machinery: A Rich Source of Drug Targets. Critical Reviews in Biotechnology. 31(4):295-336. Impact Factor:7.178

2008

Vyas, R., Kumar, V., Panjikar, S., Karthikeyan, S., Kishan, K. V. R., Tewari, R., & Weiss, M. S. (2008). Purification, crystallization and preliminary X-ray diffraction analysis of aspartate semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis. Acta Crystallogr. F64 (3), 167–170. Impact Factor: 0.799