Koyeli Mapa | Department of Life Sciences

Profile

Koyeli
Mapa
Assistant Professor
Department of Life Sciences
School of Natural Sciences (SoNS)
214
Block-R, Shiv Nadar University
Dadri Uttar Pradesh
India
9999101748
Extn: 
138
Profile Summary 

Koyeli obtained an MBBS from Calcutta Medical College following which she moved from medicine to basic research. After a brief stint at the Indian Institute of Science (IISc), Bangalore, she moved to Germany for her doctoral studies. Subsequently, she graduated with “summa cum laude” from the Medical faculty of Munich University (LMU), Germany, as a fellow of the prestigious International Max Planck Research School (IMPRS). Back in India, she received the Innovative Young Biotechnologist Award (IYBA) from the Department of Biotechnology, Government of India and worked as an IYBA fellow in the CSIR-Institute of Genomics and Integrative Biology, Delhi, before joining Shiv Nadar University. Koyeli is interested in delineating the role of molecular chaperones in heath and misfolding-induced diseases such as neurodegenerative disorders. Simultaneously, she is interested in deciphering the stress response pathways of mitochondria, the cellular power-house and how mitochondrial dysfunction happens during various pathological conditions. Koyeli has published several research papers in various journals of high international repute.

Educational Qualifications 
2009
PhD in Biochemistry
Ludwig Maximilian University, Munich
2002
MBBS
Calcutta Medical College, University of Calcutta
Work Experience 
07/15Present
Assistant Professor
Shiv Nadar University
Dadri, Gautam Budh nagar, UP
I currently work here
06/10
20102015
05/15
IYBA Fellow
CSIR-IGIB
Delhi
08/05Present
Doctoral student (IMPRS graduate school)
Institute of Physiological chemistry, LMU, Munich
Munich, Germany
I currently work here
20042005
IMPRS Fellow
Technical University Dresden, Germany
Dresden, Germany
20032004
JRF
IISc, Bangalore
Bangalore
20012002
Medical Intern
Calcutta Medical College and Hospital
Calcutta
Teaching & Research Interests: 

Research Interests

Protein homeostasis, molecular chaperones, cellular stress response pathways, mitochondrial biogenesis

Teaching interests

Animal physiology, Biology of Infectious diseases, Recombinant DNA technology

Awards(Selected): 
2009

Innovative Young Biotechnologist Award (IYBA) from DBT, India

2005

Fellowship from International Max Planck Research School (IMPRS), Munich, Germany for pursuing graduate research

2004

Fellowship from International Max Planck Research School (IMPRS), Dresden, Germany for pursuing graduate research

Scholarly Activity

Publication List

Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks. Ghosh A, Gangadharan A, Verma M, Das S, Matai L, Dash DP, Dash D*, Mapa K*, Chakraborty K*. Cell Mol Life Sci. 2019 Jan 25. (*equally contributing senior author) doi:10.1007/s00018-019-03013-8. . Impact factor: 6.7

Monitoring conformational heterogeneity of DnaK lid domain during its functional chaperone cycle.Banerjee R, Jayaraj GG, Peter J, Kumar V, Mapa K*. (*corresponding author). FEBS Journal 2016 Aug;283(15):2853-68. . Impact factor: 4.5

Banerjee R, Gladkova C, Mapa K, Witte G, Mokranjac D. Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein. Elife. 2015 Dec 29;4. pii: e11897. doi: 10.7554/eLife.11897. Impact factor: 9.32

Nagpal S, Tiwari S, Mapa K*, Thukral L*. Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding. PLoS Comput Biol. 2015 Sep 22;11(9):e1004496.   (* joint corresponding authors). Impact factor: 4.62

Kumar S, Mapa K, Maiti S. Understanding the effect of LNA and 2´-O methyl modification on the hybridization thermodynamics of miRNA-mRNA pair in the presence and absence of AfPiwi protein. Biochemistry. 2014 Feb 24.  Impact factor: 3.42

Sikor M, Mapa K, Voith von Voithenberg L, Mokranjac D, and Lamb DC. Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET. EMBO J. 2013 Apr 26. (2013) 32, 1639 - 1649. Impact factor: 10.0

Agarwala P, Pandey S, Mapa K, Maiti S. G-quadruplex augments translation in 5' Untranslated Region of Transforming Growth Factor β2 (TGFβ2). Biochemistry. 2013 Mar 5;52(9):1528-38. Impact factor: 3.42

Tiwari S, Kumar V, Jayaraj GG, Maiti S, Mapa K*. Unique Structural Modulation of a Non-Native Substrate by Cochaperone DnaJ. Biochemistry. 2013 Feb 12;52(6):1011-8.(*corresponding author). Impact factor: 3.42

Mapa K*, Tiwari S, Kumar V, Jayaraj GG and Maiti S. Information encoded in non-native states drives substrate-chaperone pairing. Structure 2012 Sep 5;20(9):1562-73. (*corresponding author). Impact factor: 6.33

Kumar S, Bose D, Suryawanshi H, Sabharwal H, Mapa K, Maiti S. Specificity of RSG-1.2 peptide binding to RRE-IIB RNA element of HIV-1 over Rev peptide is mainly enthalpic in origin. PLoS One. 2011;6(8):e23300. Epub 2011 Aug 10. Impact factor: 4.0

Popov-Celeketic D, Waegemann K, Mapa K, Neupert W and Mokranjac D. Role of the import motor in insertion of transmembrane segments by the mitochondrial TIM23 complex.EMBO Rep. 2011 Jun;12(6):542-8. Impact factor: 7.8

Mapa K, Sikor M, Kudryavstev V, Waegemann K, Kalinin S, Seidel CAM, Neupert W, Lamb DC and Mokranjac D.The Conformational dynamics of the mitochondrial Hsp70 chaperone. Mol Cell. 2010 Apr 9;38(1):89-100. Impact factor: 13.5

Blamowska M, Sichting M, Mapa K, Mokranjac D,Neupert W and Hell K. ATPase Domain and Interdomain Linker Play a Key Role in Aggregation of Mitochondrial Hsp70 Chaperone Ssc1. J Biol Chem. 2010 Feb 12;285(7):4423-31. Impact factor: 5.5

Mokranjac D, Sichting M, Popov-Celeketic D, Mapa K, Gevorkyan-Airapetov L, Zohary K, Hell K, Azem A, Neupert W. Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria. Mol Biol Cell. 2009 Mar; 20(5):1400-7. Impact factor: 5.5

Gevorkyan-Airapetov L, Zohary K, Popov-Celeketic DA, Mapa K, Hell K, Neupert W, Azem A, Mokranjac D. Interaction of tim23 with tim50 is essential for protein translocation by the mitochondrial tim23 complex. J Biol Chem. 2009 Feb 20;284(8):4865-72. Impact factor: 5.5

Popov-Celeketić D*, Mapa K*, Neupert W, Mokranjac D.Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria. EMBO J. 2008 May 21;27(10):1469-80. (*Equally contributing first authors). Impact factor: 8.0

Dhar D*, Mapa K.*, Pudi R., Srinivasan P., Bodhinathan K., Das S. Human ribosomal protein L18a interacts with hepatitis C virus internal ribosome entry site. Arch Virol. 2006Mar;151(3) :509-24. (*Equally contributing first authors). Impact factor: 1.8

Bhattacharyya S., Mapa K., Prabhavathi S., Sudhamani SR., Menon PK., John KP. ,Shivaram C., Amarnath S., Das S. Phylogenetic conservation of the stem-loop III structure of the 5' untranslated region of Hepatitis C virus RNA among natural variants in samples collected from Southern India. Arch Virol. 2004 May; 149(5): 1015-26. Impact factor: 1.8

 

 

Details of the sponsored research projects

1. DBT project under basic science scheme 2019-22 (Principal Investigator, 2nd PI; Dr. Swasti Raychaudhuri, CSIR-CCMB).

Title of the project: "A systemic investigation on sub-compartment specific proteotoxicity in mitochondria and the adaptive response mechanisms

Sanctioned budget: 50 Lakhs INR (recurring).

Status: Recommended

2. DST-SERB Research Grant under Young scientist Scheme 2015-18 (Principal Investigator).

Title of the project: "Delineation of conformational allostery of Hsp110 molecular chaperones".

Sanctioned budget: 29.36 Lakhs INR.

Status: completed

3. DBT Innovative Young Biotechnologist Award, 2009 (2010-2015) (Principal Investigator).

Title of the project: "Intracellular protein conformational dynamics".

Sanctioned budget: 72 Lakhs INR.

 Status: completed