Soumya Pati | Department of Life Sciences

Profile

Soumya
Pati
Assistant Professor
Department of Life Sciences
School of Natural Sciences (SoNS)
Shiv Nadar University
Gautam Buddha Nagar Uttar Pradesh
India
Profile Summary 

Dr. Soumya Pati gained her PhD from the University of Delhi & National Institute of Immunology during 2009, in the area of Biomedical Sciences, and got extensive training in reconstitution of hematopoietic system in lethally irradiated host using genetically manipulated hematopoietic stem cells. Following this she joined the Dept.of Neuroscience, School of Medical Sciences, University Sains Malaysia as a postdoctoral fellow and worked in the area involving "isolation and long-term maintenance of embryonic stratial stem cells (ESSCs) from E18 rat embryod to study crucial factors that governs neurogenic poetntial of striatum, also known as "third area in the neurogenesis, or the area where new neurons are born". Her work led to discovery of novel microRNAs crucial for ESSCs maintainance in brain. During her tenure, she recieved many grant awards to support her research work at USM. In 2011, she joined Baylor College of Medicine, Texas, USA to work on “detection of novel biomarkers in idiopathic autism using integrative system biology”. Based on her preliminary findings she received one of the prestigious grant award from Autism Speaks foundation as an independent investigator, USA. During her tenure, she also worked as a visiting fellow for two months in Stanford University to get advanced training in generation and characterization of patient-derived iPSCs.

At present, Dr.Pati's group works in the area of neurological disease modeling, and trying to address many unsolved queries of human brain such as, i) important players controlling microglial biology and behavior across the human brain ages,  ii) regulatory factors underlying microglia-dependent neuroinflammation, iii) deciphering metabolic biomarkers in neural fate specifications of human brain and their implications in neurological diseases.

As a part of collaborative research, Dr.Pati's laboratory is also commited towards desiging cellular disease models to understand host-pathogen intreractions underlying deadly parasitic diseases such as cerebral malaria and kalazarDr.Pati has published 25 publications, 2 patents; 1 published and the other filed and two book chapters. 

 

 

 

Educational Qualifications 
2009
Ph.D in Biomedical sciences
National Institute of Immunology & University of Delhi, North Campus, Delhi.
1998
Masters in Biotechnology
GGD Central University, Bilaspur
1996
BSc in Biology
Utkal University
Work Experience 
03/15Present
Assistant Professor,
Shiv Nadar University, Greater Noida, U.P,
R-222, Research Block, School of Natural Sciences
I currently work here
20112014
Postdoctoral Fellow,
Jan & Dan Duncan Neurological Research Institute, Baylor College of Medicine,
Houston, Texas, USA
20092011
USM Postdoctoral Fellow,
University of Science, Malaysia,
Medical Campus, USM, Kota Bharu, Malaysia
20082009
Senior Research Fellow,
National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi-110054,
Gene Regulation Laboratory
Teaching & Research Interests: 

Courses undertaken since 2015 for teaching graduate and undergraduates:

CCC 512: Brain Sciences and Cognition (CCC for undergrad-3 credits)

CCC401:  Research methodology (From UG & Pre-PhD fellows-3credits)

BIO701: Advanced Cell & Molecular Biology (Core course for PhD fellows-2 credits)

BIO313/526: Cell Signaling & Neuroscience (Major Elective for BS. Biotechnology/pre-PhD-credit 4)

Developed the curriculum for Brain Sciences and Cognition as CCC 512.

Developed Cell Signaling and Neuroscience both at UG and Pre-PhD major electives with basic and advanced course curriculums.

Research Areas:

Determining the metabolic biomarkers involved in neurogenesis and neural fate commitments in human brain and their implications in neurological disease modeling: The study involves generation of iPSC lines and iPSC-derived neurons from indian patients suffering from idiopathic autism. These patient-derived brain cells would then be used as cellular disease models to delineate both metabolomics and transcriptomic signatures for identifying disease-specific metabolic biomarkers.

Untangling complex molecular mechanisms governing plasticity of microglia in human brain: Our laboratory is trying to understand the gene regulatory mechanism in microglia cells, which primes their plastic behaviors, including immunomodulation and neuroprotection in human brain.

Developing cellular disease models to understand host-pathogen interactions for drug discovery platform: Understanding cellular damages triggered by invading pathogen or pathogen derived factors, requires utilization of robust cellular disease models in vitro, which can unravel the novel molecular targets. Our laboratory is committed towards exploring neuro-inflammatory signals underlying onset of pathogenic manifestations of cerebral malaria and also the host innate immune-sensors involved in kalazar.

Students continuing/completed PhD

Ayana Rajgopal, PhD (Degree awarded Jan 2019)- Main-supervisor

Amrita Chakrabarti (Final year PhD)- Main Supervisor-Thesis submission in Dec2019

Abhishek Shivappagowdar (Final year PhD)- Joint-supervisor- Thesis submission in Dec2019

Deepika Kannan (Final year PhD)-Co-Supervisor- Thesis submission in Dec2019

Rahul Hadda (PhD enrolled 2017 Aug)- Main Supervisor

Jyoti Kumari (PhD enrolled 2017 Dec), DST Inspire Fellow- Main Supervisor

Waseem Dar (PhD enrolled 2019 september)-Main Supervisor

 

Conferences (Select): 

Selected Conferences:

Invited Speaker in “Multiscale Simulations and Mathematical Modelling of Complex Biological Systems MSMM2019” held on Jan 30-Feb 01, 2019 in New Delhi, India. Title of Talk:In Silico Mapping of Metabolome Reveals Novel Metabolomic Signatures in hESC-derived Glutamatergic Neurons.

Invited as National Speaker at World Neurocongress-2017 (WNC-2017), Theme: Neurogenomics and Stem Cell Therapy, organized by Indian academy of neuroscience & Interdisciplinary Brain Research Centre (IBRC), Aligarh Muslim University, Aligarh, 9 th to 10th December, 2017. Title of talk: Integrated system biology based detection of novel biomarkers in idiopathic autism.

Invited Speaker at National Conference on Recent Trends in Cell & Molecular Biology Research (RTCMBR) on27 & 28 October 2017. Title of talk: CRISPR/Cas9 Gene editing based attenuation of Sphingosine dynamics suggests Sphingosine Kinase-1 as a potential biomarker for idiopathic autism.

Invited speaker by UGC-Human Resource Development Centre, Jawaharlal Nehru University to deliver a lecture in the 10th Orientation Programme conducted on 13th February to 10th March, 2017 at the UGCHRDC, JNU.

Invited Oral presenter during One day symposium on “Emerging Trends in Translational Research in India” (9th April 2016), Designing of Novel Drug targets for Cerebral Malaria. Title of talk: Designing of Novel Drug targets for Cerebral Malaria.

Invited Oral presenter: Soumya Pati, Xu Han, Mirjana Maletic-Savatic, Pathway mapping of transcriptome revealed potential neuronal fate discriminators in human embryonic stem cell derived neural progenitors in 6th Annual Congress of Regenerative Medicine & Stem Cell-2013 (RMSC- 2013), Dalian Hi-tech Industrial Zone, LN 116025, China.

Invited Oral presenter at 2nd World Congress on Cell Science and Stem Cell Research, San Antonio, TX (published as Soumya Pati, Li-hua Ma, Wendy Han, Cemal Karakas and Mirjana Maletic Savatic, J Cell Sci Ther 2012, 3:8).Title of Talk: NMR based metabolomic profiling of human embryonic stem cell derived neurons,

Selected Oral Presenter at UMT 9th International Symposium on Sustainability Science and Management, University of Malaysia, Malaysia (2010 May9th/10th). Title of Talk: Long-term culture of rat embryo derived neural stem cells under conditioned microenvironment: Implications in stem cell fate specifications. 

Awards(Selected): 
20102019
  • 2019 Best Oral Presenter at National Congress of Parasitology & Global Malaria Elimination held during 26th-to 28th September, Jawaharlal Nehru University, Delhi-110067.
  • 2019 Best poster Prize at 7th International Symposium on Current Trends in Drug Discovery Research in CTDDR 2019 held during Feb 20 to 23rd in CDRI, Lucknow. 
  • 2018 Best Oral Presenter in International Conference on Integrative Chemistry, Biology & Translational Medicine (ICBTM), February 25-26, 2019 at University of Delhi, Delhi, India.
  • 2010 Best Oral Presenter, UMT 9th International Symposium on Sustainability Science and Management, University of Malaysia, Malaysia.
  • 2003 Best Poster Presentation, 4th annual Symposium on Frontiers in Biomedical Research, University of Delhi.
  • 2002 Best Poster Presentation, International Conference, LASTEC Center, Delhi, India.

NATIONAL & INTERNATIONAL GRANT AWARDS:

  • 2019-22: Cognitive Scientific Research Initiative Grant, DST (CSRI-DST), (~INR 54 Lakh)
  • 2012-14: Meixner Postdoctoral Fellowship in Translational Research, Autism Speaks Foundation, USA, (INR 60 Lakh).
  • 2011: AO Spine South East Asian Research Grant Award, South East Asian Spine Society, AOSPINE Asia Pacific, Hong kong INR 5.5 Lakh
  • 2010-13: Fundamental Research Grant Award, Ministry of Education, Government of Malaysia, INR 12 Lakh
  • 2010-11: Research and Development seed grant award, University of Science, Malaysia, INR 15 Lakh
  • 2010: DST Fast Track Young Scientist Award, Department of Science & Technology, New Delhi, INR 17 Lakh

Scholarly Activity

Projects Undergoing:

  • Cognitive Scientific Research Initiative Grant funded by DST (2019- ongoing): Unravelling Novel Metabolic Biomarkers in Children with Idiopathic Autism in India using IPSC-based Neurological Disease Remodeling: The study involves generation of iPSC lines and iPSC-derived neurons from indian patients suffering from idiopathic autism. These patient-derived brain cells would then be used as cellular disease models to delineate both metabolomics and transcriptomic signatures for identifying disease-specific metabolic biomarkers.
  • Untangling complex molecular mechanisms governing plasticity of microglia in human brain: Our laboratory is trying to understand the gene regulatory mechanism in microglia cells, which primes their plastic behaviors, including immunomodulation and neuroprotection in human brain.

Peer reviewed publications:

  1. Reduction of sphingosine kinase 1 phosphorylation and activity in plasmodium-infected Erythrocytes. Raj Kumar Sah#, Soumya Pati# Monika Saini, Pon Arunachalam Boopathi, Sanjay Kumar Kochar, Dhanpat Kumar Kochar, Ashis Das, Shailja Singh. Front. Cell Dev. Biol., 03 March 2020. [#Co-first author]. [IF-5.19]
  2. Plasmodium Perforin-like Protein pores on the host cell membrane contribute in its multistage growth and erythrocyte senescence, by  Swati Garg, Abhishek Shivappagowdar, Rahul S Hada, Rajagopal Ayana, Chandramohan Bathula, Subhabrata Sen, Inderjeet Kalia, Soumya Pati, Agam P Singh, Shailja Singh, Front. Cell. Infect. Microbiol. 24 March 2020. [IF-3.518]
  3. Targeted Repression of Plasmodium Apicortin by host micro RNA impairs malaria parasite growth and invasion, Malabika Chakrabarti, Swati Garg, Ayana Rajagopal, Soumya Pati, and Shailja Singh, accepted in Disease Models & Mechanisms, March 2020. [IF-4.95]
  4. Abhishek Shivappagowdar#, Soumya Pati#*, Chintam Narayana, Ayana R, Himani Kaushik, Raj Sah, Swati Garg, Ashish Khanna, Jyoti Kumari, Lalit Garg, Ram Sagar*, and Shailja Singh*. A small bioactive glycoside inhibits epsilon toxin and protects host cell death. Accepted in Disease Models & Mechanisms (August 2019). *Co-first & Corresponding author. [IF-4.95]
  5. Srivastava A, Garg S, Jain R, Ayana R, Kaushik H, Garg L, Pati S, Singh S. Identification and functional characterization of a bacterial homologue of Zeta toxin in Leishmania donovani. FEBS Lett. 2019 Jun;593(11):1223-1235. [IF-2.67]
  6. Yadav P, Ayana R, Garg S, Jain R, Sah R, Joshi N, Pati S, Singh S. Plasmodium palmitoylation machinery engineered in E. coli for high-throughput screening of palmitoyl acyl-transferase inhibitors. FEBS Open Bio. 2019;9(2):248–264. [IF-1.78]
  7. Perumal G, Chakrabarti A, Grewal HS, Pati S, Singh S, Arora HS. Enhanced antibacterial properties and the cellular response of stainless steel through friction stir processing. Biofouling. 2019 Feb;35(2):187-203 [IF-2.87].
  8. Ayana R, Singh S, Pati S*. Deconvolution of Human Brain Cell Type Transcriptomes Unraveled Microglia-  Specific Potential Biomarkers. Frontiers in Neurology. 2018; 9:266. *Corresponding author. [IF-3.55]
  9. Ayana R, Singh S, Pati S*. Decoding Crucial LncRNAs Implicated in Neurogenesis and Neurological Disorders. Stem Cells Dev. 2017 15; 26(8):541-553. *Corresponding author. [IF-3.14]
  10. Ayana, R., Yadav, P., Kumari, R., Ramu, D., Garg, S., Pati S., & Singh, S. (2018). Identification and Characterization of a Novel Palmitoyl Acyltransferase as a Druggable Rheostat of Dynamic Palmitoylome in L. donovani. Frontiers in Cellular and Infection Microbiology, 8, 186. [IF-3.51]
  11. Gopinath Perumal, Aditya Ayyagari, Amrita Chakrabarti, Deepika Kannan, Soumya Pati, Harpreet Singh Grewal, Sundeep Mukherjee, Shailja Singh, and Harpreet Singh Arora. Friction Stir Processing of Stainless Steel for Ascertaining Its Superlative Performance in Bioimplant Applications, ACS Appl. Mater. Interfaces. 201794236615-36631. [IF-7.5]
  12. Sharma V, Amarnath N, Shukla S, Ayana R, Kumar N, Yadav N, Kannan D, Sehrawat S, Pati S, Lochab B, Singh S. (2018) Benzoxazine derivatives of phytophenols show anti-plasmodial activity via sodium homeostasis disruption. Bioorg Med Chem Lett.15;28(9):1629-1637. [IF-2.44]
  13. Ramu, S. Garg, R. Ayana, A. K. Keerthana, V. Sharma, S. Sen, S. Pati, S. Singh*. Novel β-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising anti-leishmanial activity, Biochem Pharmacol. 2017 1;129:26-42 [IF-4.624]
  14. Soumya Pati, Sangu Muthuraju, Raisah Ab. Hadi, Tee Jong Huat, Shailja Singh, Mirjana Maletic-Savatic, Jafri Malin Abdullah, Hasnan Jaafar, Neurogenic plasticity of mesenchymal stem cell, an alluring cellular replacement for traumatic brain injury. Curr Stem Cell Res Ther. 2016; 11(2):149-57. Review. [F-2.68].
  15. Soumya Pati, NorEntan Supeno, Sangu Muthuraju, Raisah Ab. Hadi, Abdul Rahman I Ghani, MD, Fauziah M Idris, MD; Mirjana M Savatic, Jafri M Abdullah, Hasnan Jaafar, MicroRNA profiling Reveals unique miRNA signatures in IGF-1 treated embryonic striatal stem cell fate decisions in striatal neurogenesis in vitro. (Biomed Res Int. 2014; 2014:503162. [IF-3.1]
  16. Muthuraju, S., & Pati, S. (2014). Effect of Hypobaric Hypoxia on Cognitive Functions and Potential Therapeutic Agents. The Malaysian Journal of Medical Sciences: MJMS, 21(Spec Issue), 41–45.
  17. Sangu Muthuraju, Mohamed Rafiqul Islam, Soumya Pati, Hasnan Jaafar, Jafri Malin Abdullah, and Kamaruddin Mohd. Yusoff, (2015). Normobaric hyperoxia treatment prevents early alteration in dopamine level in mice striatum after fluid percussion injury: a biochemical approach. International Journal of Neuroscience, 2015; 125(9):686-92 [IF-1.85]
  18. Tee Jong Huat, Amir Ali Khan, Soumya Pati, Jafri Malin Abdullah & Hasnan Jaafar, IGF-1 enhances cell proliferation and survival during early differentiation of mesenchymal stem cells to neural progenitor-like cells. BMC Neurosci. 2014 Jul 22; 15:91. [IF-2.7]
  19. Muthuraju, S., Taha, S., Pati, S., Rafique, M., Jaafar, H., & Abdullah, J. M. (2013). Normabaric Hyperoxia Treatment Improved Locomotor Activity of C57BL/6J Mice through Enhancing Dopamine Genes Following Fluid-Percussion Injury in Striatum. International Journal of Biomedical Science: IJBS, 9(4), 194–204.
  20. Supeno NE, Pati S*, Hadi RA, Ghani ARI, Mustafa Z, Abdullah JM, Idris FM, Han X, Jaafar H (2013). IGF-acts as Controlling Switch for Long-term Proliferation and Maintenance of EGF/FGF responsive Striatal Neural Stem Cells (*Co-first authors). Int J Med Sci. [IF-2.4]
  21. Sangu Muthuraju, Syed Taha, Soumya Pati, Mohamed Rafique, Hasnan Jaafar, Jafri Malin Abdullah (2013). Normabaric Hyperoxia Treatment Improved Locomotor Activity of C57BL/6J Mice through Enhancing Dopamine Genes Following Fluid-Percussion Injury in Striatum. Int J Biomed Sci.2013 dec 9(4):194-204. PMID: 24711754. (IF-0.56)
  22. Muthuraju, S., Pati, S., Rafiqul, M., Abdullah, J.M. and Jaafar, H (2013). Effect of normabaric hyperoxia treatment on neuronal damage following fluid percussion injury in the striatum of mice: A morphological approach. J. Biosci. 38 (1–11). PMID: 23385817 (IF-1.8)
  23. Supeno NE, Pati S*, Hadi RA, Ghani ARI, Mustafa Z, Abdullah JM, Idris FM, Han X, Jaafar H (2013). IGF-Acts as Controlling Switch for Long-term Proliferation and Maintenance of EGF/FGFresponsive Striatal Neural Stem Cells (*Co-first authors). Int J Med Sci. 10(5):522-531. PMID: 23532711 (IF-2.4).
  24. Sangu Muthuraju, Soumya Pati, Mohammad Rafiqul, Jafri Malin Abdullah, Hasnan Jaafar (2012). IntelliCage provides voluntary exercise and an enriched environment, improving locomotive activity in mice following fluid percussion injury. Basal Ganglia 2012; 2(3):143-151.
  25. Muthuraju, S., Maiti, P., Pati, S., Solanki, P., Sharma, A.K., Singh, S.B., Prasad, D., Ilavazhagan, G (2011). Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia. Eur J Pharmacol. 672(1-3):96-105. PMID: 21924263. (IF-3.12)
  26. Muthuraju, S., Maiti, P., Solanki, P., Sharma, A.K., Pati, S., Singh, S.B., Prasad, D., Ilavazhagan, G (2011). Possible role of cholinesterase inhibitors on memory consolidation following hypobaric hypoxia of rats. Int J Neurosci. 121(5):279-88. PMID: 21348795. (IF-1.75)
  27. Pati, S., Kalra, O.P., and Mukhopadhyay, A (2011). Foe turned friend: multiple functional roles attributable to hyper-activating stem cell factor receptor mutant in regeneration of the hematopoietic cell compartment, Cell Proliferation, 44(1):10-8. PMID:21199006. (IF-4.9)
  28. Pati, S., Gurudutta, G.U., Kalra, O.P., and Mukhopadhyay, A (2010). The structural insights of stem cell factor receptor (c-Kit) interaction with tyrosine phosphatase-2 (Shp-2): An In silico analysis. BMC Res Notes, 3:14. PMID:20205869. (1.60)

Patent published:    

  1. AN APPARTUS AND A METHOD FOR PROCESSING STAINLESS STEEL AND AN IMPROVED STAINLESS STEEL      FOR BIOIMPLANTS THEREOF, H. Singh, H.S. Grewal, S. Pati, S. Singh, G. Perumal, July 2017, App.No. 201711025604.  
  2. GLYCOSIDE BASED ANTI-TOXIN FOR EPSILON INTOXICATION AND PREPARATION METHOD THEREOF, published in The Patent Office Journal No. 12/2020 Dated 20/03/2020, Application No.201811034958 A.  Chintam Narayana, Abhishek Shivappagowdar, Ram Sagar, Soumya Pati* and Shailja Singh* 

Conference Proceedings (full paper): Ekta Kapoor, Vinith Johnson, Dr.Soumya Pati, Dr.Vijay Kumar Chakka, Fourier Decomposition Method based descriptor of EEG signals to identify Dementia, 2016 IEEE Region 10 Conference (TENCON) — Proceedings of the Internatio nal Conference (2476-2480).

Chapters/Books: Pati S., Singh S. (2017) Unraveling the Role of Long Noncoding RNAs in Pluripotent Stem Cell-Based Neuronal Commitment and Neurogenesis. In: Mukhopadhyay A. (eds) Regenerative Medicine: Laboratory to Clinic. Springer, Singapore. Online ISBN: 978-981-10-3701-6

Pati S., Mukhopadhyay A. (2012) Recovery of the Bone Marrow in Lethally Irradiated Host: Role of Hyper-Activated Stem Cell Factor Receptor. In: Hayat M. (eds) Stem Cells and Cancer Stem Cells, Volume 7. Stem Cells and Cancer Stem Cells, vol 7. Springer, Dordrecht. Online ISBN: 978-94-007- 4285-7