Dr. Kiran Lokhande | Department of Life Sciences

Profile

Dr. Kiran
Bharat
Lokhande
Post-Doctoral Fellow
Department of Life Sciences
School of Natural Sciences (SNS)
A313, Shiv Nadar University
Greater Noida, Uttar Pradesh
India
+91 8208123287
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Profile Summary 

Research Area: Structural Bioinformatics and Drug Discovery.

Educational Qualifications 
2022
Ph.D. (Bioinformatics)
Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, INDIA
2016
M.S. Pharm. (Pharmacoinformatics)
National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Bihar, INDIA
2014
B. Pharmacy
SMPs College of Pharmacy, Akluj, Solapur, Maharashtra, INDIA
Work Experience 
09/22Present
2022
Post Doctoral Fellow,
Department of Life Sciences, School of Natural Sciences, Shiv Nadar University,
Delhi-NCR, INDIA
I currently work here
06/22
08/22
Research Associate,
Gujarat Biotechnology Research Centre (GBRC), Department of Science & Technology, Govt. of Gujarat,
Gujarat, INDIA
06/19
06/22
ICMR-Senior Research Fellow,
Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune,
Pune, INDIA
11/18
06/19
DST-SERB: Senior Research Fellow,
Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth,
Pune, INDIA
10/16
09/18
DST-SERB: Junior Research Fellow,
Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune,
Pune, INDIA
Awards(Selected): 
2020

Drug Discovery Hackathon 2020 (Phase-I): Solution for drug discovery against Covid-19 is selected and awarded with cash prize of Rs. 25,000/- in DDH2020 Phase-I, joint initiative of AICTE, CSIR and supported by Office of Principal Scientific Advisor, Govt. of India, NIC and MyGov.

2020

Institute of Scholars (InSC) Research Excellence Award 2020 

20192022

ICMR: Senior Research Fellowship

20182019

Senior Research Fellowship of DST-SERB funded by Department of Science Technology-Science and Engineering Research Board, Govt. of India.

20162018

Junior Research Fellowship of DST-SERB funded by Department of Science Technology-Science and Engineering Research Board, Govt. of India.

20142016

Fellowship of NIPER funded by Ministry of Chemicals and Fertilizers, Govt. of India, during the course of M.S. Pharm.

2014

NIPER JEE 2014

2014

GPAT 2014

Scholarly Activity

PROFESSIONAL MEMBERSHIP & REVIEWER

1. Life-Time Member at Institute of Scholars (InSc), India.
2. Journal of Biomolecular Structure and Dynamics, Taylor Francis.
3. Computers in Biology and Medicine, Elsevier.
4. Computational and Structural Biotechnology Journal, Elsevier.
5. Medical Hypotheses, Elsevier.
6. Informatics in Medicine Unlocked, Elsevier.
7. Bioinformatics and Biology Insights, SAGE Journals.
8. Advances and Applications in Bioinformatics and Chemistry, Dovepress.
9. International Journal of Genearal Medicine, Dovepress.
10. Scientific Reports: Nature Publication Group

Journal Publications (accepted or published)

INTERNATIONAL PUBLICATIONS:

  1. Doiphode, S., Lokhande, K. B., Ghosh, P., Swamy, K. V., & Nagar, S. (2022). Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) by resveratrol derivatives in cancer therapy: in silico approach. Journal of biomolecular structure & dynamics, 1–16. Advance online publication. https://doi.org/10.1080/07391102.2022.2135599. [IF=5.325].
  2. Singh, I. A., Lokhande, K. B., Swamy, K. V. (2022). Identification and Screening of Novel Anti-Cancer Compounds for Aurora Kinase-A from Chemical Database. DrugResearch, 10.1055/a-1877-4693. Advance online publication. https://doi.org/10.1055/a- 1877-4693 [IF=1.864].
  3. Chaudhari, A. M., Joshi, M., Kumar, D., Patel, A., Lokhande, K. B., Krishnan, A., Hanack, K., Filipek, S., Liepmann, D., Renugopalakrishnan, V., Paulmurugan, R., Joshi, C. (2022). Evaluation of immune evasion in SARS-CoV-2 Delta and Omicron variants. Computational and structural biotechnology journal, 20, 4501–4516. https://doi.org/10.1016/j.csbj.2022.08.010 [IF=6.155].
  4. More-Adate, P., Lokhande, K. B., Swamy, K. V., Nagar, S., Baheti, A. (2022). GC-MS profiling of Bauhinia variegata major phytoconstituents with computational identification of potential lead inhibitors of SARS-CoV-2 Mpro. Computers in biology and medicine, 147, 105679. https://doi.org/10.1016/j.compbiomed.2022.105679 [IF=6.698].
  5. Sagar Nagare, Kiran Bharat Lokhande, K. Venkateswara Swamy.Molecular Docking and simulation studies of Flavanone and its Derived compounds on PI3K-AKT Pathway Targeting against Cancer. Current Drug Discovery Technologies. Advance online publication. https://doi.org/10.2174/1570163819666220526150152 [IF=1.72].
  6. Kiran Bharat Lokhande, Sarika Vishnu Pawar, Smriti Madkaiker, Neelu Nawani, Swamy K. Venkateswara, Payel Ghosh. (2022). High Throughput Virtual Screening and Molecular Dynamics Simulation analysis of phytomolecules against BfmR of Acinetobacter baumannii: Anti-virulent drug development campaign. Journal of biomolecular structure & dynamics, 1–15. Advance online publication. https://doi.org/10.1080/07391102.2022.2038271 [IF=5.325].
  7. Asha Thomas,Manjiri Bhosale, Lokhande K. B., Swamy K. V., Chitlange S. S. (2022). Role ofNitrogen containing heterocyclic compounds in Acyl co-A carboxylase carboxyltransferase: Docking with dynamic simulation studies. Journal of Research in Pharmacy, 26(1):035- 043. http://dx.doi.org/10.29228/jrp.1 [IF=0.884]. 
  8. Dutta A. D., Raj A.K., Lokhande K. B., Mitruka M., Swamy K. V., Pal J. K., Sarode S. C., Sharma N. K. (2022). Detection of Oncometabolite Nicotine Imine in the Nail of Oral Cancer Patients; Predicted as an Inhibitor of DNMT1. Current Chemical Biology,15(4):301-309.http://dx.doi.org/10.2174/2212796816666211223105911 [IF=1.1].
  9. Abhijeet Karale, Lokhande KB, Niraj Shende, K. V. Swamy, Rajeev Dhere, Neelu Nawani, Asha Mallya. (2021). Transferrin binding protein-B from Neisseria meningitidis C as a novel carrier protein in glycoconjugate preparation: an in silico approach. Journal of biomolecular structure & dynamics, 1–11. Advance online publication. https://doi.org/10.1080/07391102.2021.1994878 [IF=5.325].
  10. Patel R, Raj AK, Lokhande KB, Almasri MA, Alzahrani KJ, Almeslet AS, Swamy KV, Sarode GS, Sarode SC, Patil S, Sharma NK. (2021). Detection of Nail Oncometabolite SAICAR in Oral Cancer Patients and Its Molecular Interactions with PKM2 Enzyme. Int. J. Environ. Res. Public Health,18(21):11225. https://doi.org/10.3390/ijerph182111225 [IF=4.614]
  11. Lokhande KB, Ghosh, P., Nagar, S., Venkateswara Swamy, K. (2021). Novel B, C-ring truncated deguelin derivatives reveals as potential inhibitors of cyclin D1 and cyclin E using molecular docking and molecular dynamic simulation. Molecular Diversity. Advance online publication. https://doi.org/10.1007/s11030-021-10334-z [IF=3.364]
  12. Hritik Chandore, Ajay Kumar Raj, Kiran Bharat Lokhande, K Venkateswara Swamy, Jayanta K Pal, Nilesh Kumar Sharma. (2021). An Intracellular Tripeptide Arg-His-Trp of Serum Origin Detected in MCF-7 Cells Is a Possible Agonist to β2 Adrenoceptor. Protein & Peptide Letters, Advance online publication. https://doi.org/10.2174/0929866528666210816114901 [IF=1.927].
  13. Lokhande, K. B., Banerjee, T., Swamy, K. V., Ghosh, P., Deshpande, M. (2021). An in silico scientific basis for LL-37 as a therapeutic for Covid-19. Proteins, 10.1002/prot.26198. Advance online publication. https://doi.org/10.1002/prot.26198 [IF=4.088].
  14. Pulakuntla, S., Lokhande, K. B., Padmavathi, P., Pal, M., Swamy, K. V., Sadasivam, J., Singh, S. A., Aramgam, S. L., Reddy, V. D. (2021). Mutational analysis in international isolates and drug repurposing against SARS-CoV-2 spike protein: molecular docking and simulation approach. Virusdisease, 1–13. Advance online publication. https://doi.org/10.1007/s13337-021-00720-4 [IF=1.292].
  15. Pandey, K., Lokhande, K. B., Swamy, K. V., Nagar, S., Dake, M. (2021). In SilicoExploration of Phytoconstituents From Phyllanthus emblica and Aegle marmelos as Potential Therapeutics Against SARS-CoV-2 RdRp. Bioinformatics and biology insights, 15. https://doi.org/10.1177/11779322211027403 [IF=2.063].
  16. Pandey, R. K., Dikhit, M. R., Lokhande, K. B., Pandey, K., Das, P., Bimal, S. (2021). An immunoprophylactic evaluation of Ld-ODC derived HLA-A0201 restricted peptides against visceral leishmaniasis. Journal of biomolecular structure & dynamics, 1–11. Advance online publication. https://doi.org/10.1080/07391102.2021.1876773 [IF=5.325].
  17. Lokhande, K., Nawani, N., K Venkateswara, S., Pawar, S. (2020). Biflavonoids from Rhus succedanea as probable natural inhibitors against SARS-CoV-2: a molecular docking and molecular dynamics approach. Journal of biomolecular & structure dynamics, 1–13. Advance online publication. https://doi.org/10.1080/07391102.2020.1858165 [IF=5.325].
  18. Lokhande, K. B., Apte, G. R., Shrivastava, A., Singh, A., Pal, J. K., K Venkateswara Swamy, Gupta, R. K. (2020). Sensing the interactions between carbohydrate-binding agents and N-linked glycans of SARS-CoV-2 spike glycoprotein using molecular docking and simulation studies. Journal of biomolecular & structure dynamics, 1–19. Advance online publication. https://doi.org/10.1080/07391102.2020.1851303 [IF=5.325].
  19. Lokhande, K. B., Ballav, S., Yadav, R. S., Swamy, K. V., Basu, S. (2020). Probing intermolecular interactions and binding stability of kaempferol, quercetin and resveratrol derivatives with PPAR-gamma: docking, molecular dynamics and MM/GBSA approach to reveal potent PPAR-gamma agonist against cancer. Journal of biomolecular & structure dynamics, 1–11. Advance online publication. https://doi.org/10.1080/07391102.2020.1820380 [IF=5.325].
  20. Gupta, R. K., Apte, G. R., Lokhande, K. B., Mishra, S., Pal, J. K. (2020). Carbohydrate-Binding Agents: Potential of Repurposing for COVID-19 Therapy. Current protein & peptide science, 21(11), 1085–1096. https://doi.org/10.2174/1389203721666200918153717 [IF=3.118].
  21. Mansuri, A., Lokhande, K., Kore, S., Gaikwad, S., Nawani, N., Swamy, K. V., Junnarkar, M., Pawar, S. (2020). Antioxidant, anti-quorum sensing, biofilm inhibitory activities and chemical composition of Patchouli essential oil: in vitro and in silico approach. Journal of biomolecular & structure dynamics, 1–12. Advance online publication. https://doi.org/10.1080/07391102.2020.1810124 [IF=5.325].
  22. Lokhande, K. B., Ballav, S., Thosar, N., Swamy, K. V., Basu, S. (2020). Exploring conformational changes of PPAR-gamma complexed with novel kaempferol, quercetin, and resveratrol derivatives to understand binding mode assessment: a small-molecule checkmate to cancer therapy. Journal of molecular modeling, 26(9), 242. https://doi.org/10.1007/s00894-020-04488-0 [IF=2.172]
  23. Lokhande, K. B., Doiphode, S., Vyas, R., Swamy, K. V. (2020). Molecular docking and simulation studies on SARS-CoV-2 Mpro reveals Mitoxantrone, Leucovorin, Birinapant, and Dynasore as potent drugs against COVID-19. Journal of biomolecular & structure dynamics, 1–12. Advance online publication. https://doi.org/10.1080/07391102.2020.1805019 [IF=5.325].
  24. Chandani, S. R., Lokhande, K. B., Swamy, K. V., Nanda, R. K., Chitlange, S. S. (2019). Data on docking of phytoconstituents of Actinidia deliciosa on dengue viral targets. Data in brief, 25, 103996. https://doi.org/10.1016/j.dib.2019.103996 [IF=1.133].
  25. Yewale, P. P., Lokhande, K. B., Sridhar, A., Vaishnav, M., Khan, F. A., Mandal, A., Swamy, K. V., Jass, J., Nawani, N. (2020). Molecular profiling of multidrug-resistant river water isolates: insights into resistance mechanism and potential inhibitors. Environmental science and pollution research, 27(22), 27279–27292. https://doi.org/10.1007/s11356-019-05738-2 [IF=5.190].
  26. Gandhi, S. P., Lokhande, K. B., Swamy, V. K., Nanda, R. K., Chitlange, S. S. (2019). Computational data of phytoconstituents from Hibiscus rosa-sinensis on various anti-obesity targets. Data in brief, 24, 103994. https://doi.org/10.1016/j.dib.2019.103994 [IF=1.133].
  27. Sagar Rohidas Nagare, Kiran Bharat Lokhande, Kakumani Venkateswara Swamy. (2020). Molecular docking studies of flavanone and its derivatives on pi3k pathway to search for potential target against cancer. Journal of Dental Research and Review, 7(5), 26-29. https://www.jdrr.org/text.asp?2020/7/5/26/278907.
  28. Sangeeta Ballav, Kiran Bharat Lokhande, Ipshita Dabhi, Sonal Inje, Amit Ranjan, K Venkateswara Swamy, Soumya Basu. (2020). Designing novel quercetin derivatives as matrix metalloproteinase-9 inhibitors in colon carcinoma: An In vitro and in silico approach. Journal of Dental Research and Review, 7(5), 30-35. https://www.jdrr.org/text.asp?2020/7/5/30/278905.
  29. Rohit D Gupta, Krish Parekh, Vaishnavi U Warrier, Kiran Bharat Lokhande, K Venkateswara Swamy, Rajkumar S Sood, Rajesh Kumar Gupta. (2020). Purification and characterization of pectins from Abelmoschus esculentus (okra pods) and Citrus limetta (citrus peels) and in silico binding study of pectin and pectic polysaccharides with galectin-1. Journal of Dental Research and Review, 7(5), 41-48. https://www.jdrr.org/text.asp?2020/7/5/41/278902
  30. Kothawade P. B., Lokhande K. B., Swamy K.V., Chitlange S. S, Thomas A. B. (2020). Novel nitrogen-containing heterocyclic compounds in GPR109A as an anti-hyperlipidemic: Homology modeling, docking, dynamic simulation studies. J Res Pharm., 24(4): 452-463. https://doi.org/10.35333/jrp.2020.193 [IF=0.884].
  31. Thomas A. B., Shaikh A. S., Raje A., Lokhande K. B., Swamy K. V., Nagore D. H., Doke R. (2020). Herb drug interaction of Tinospora cordifolia (Willd.) Miers extract and Glimepiride: Medicinal Plants-International Journal of Phytomedicines and Related Industries, 12(4), 555-567. http://dx.doi.org/10.5958/0975-6892.2020.00068.4 [IF=3.484].
  32. Lokhande, K. B., Nagar, S., Swamy, K. V. (2019). Molecular interaction studies of Deguelin and its derivatives with Cyclin D1 and Cyclin E in cancer cell signaling pathway: The computational approach. Scientific reports, 9(1), 1778. https://doi.org/10.1038/s41598-018- 38332-6 [IF=4.996].
  33. Reddy, P. S., Lokhande, K. B., Nagar, S., Reddy, V. D., Murthy, P. S., Swamy, K. V. (2018). Molecular Modeling, Docking, Dynamics and Simulation of Gefitinib and its Derivatives with EGFR in Non-small Cell Lung Cancer. Current computer-aided drug design, 14(3), 246–252. https://doi.org/10.2174/1573409914666180228111433 [IF=1.639].
  34. Krushna, G. S., Shivaranjani, V. L., Umamaheswari, J., Srinivasulu, C., Hussain, S. A., Kareem, M. A., Reddy, V. D., Ali, D., Lokhande, K. B., Swamy, K. V., Kodidhela, L. D. (2017). In vivo and molecular docking studies using whole extract and phytocompounds of Aegle marmelos fruit protective effects against Isoproterenol-induced Myocardial infarction in rats. Biomedecine & pharmacotherapy, 91, 880–889. https://doi.org/10.1016/j.biopha.2017.04.115 [IF=7.419].

Preprints:

  1. Ipsa A. Singh, Kiran Bharat Lokhande, K. Venkateswara Swamy. (2021). Identification and Screening of Novel Anti-Cancer Compound For Aurora Kinase A From Chemical Database. ResearchSquare (Preprint). https://doi.org/10.21203/rs.3.rs-924029/v1.
  2. Rushikesh Patel, Ajay Kumar, Kiran Bharat Lokhande, KV Swamy, Nilesh Kumar Sharma. (2020). Molecular Docking and Simulation Studies Predict Lactyl-CoA as the Substrate for P300 Directed Lactylation. chemRxiv (Preprint).https://doi.org/10.26434/chemrxiv.12770360.v1.
  3. Ajay Kumar Raj, Jainish Kothari, Sethamma TN Sinchana, Kiran Lokhande, KV Swamy, Nilesh Kumar Sharma. (2020). Novel antiproliferative tripeptides block AP-1 transcriptional complex by in silico approach. bioRxiv (Preprint). https://doi.org/10.1101/2020.05.08.083972.
  4. Hritik Chandore, Ajay Kumar Raj, Kiran Bharat Lokhande, K Venkateswara Swamy, Jayanta K Pal, Nilesh Kumar Sharma. (2020). An intracellular tripeptide Arg-His-Trp of serum origin detected in MCF-7 cells is a possible agonist to 2 adrenoceptor. bioRxiv (Preprint). https://doi.org/10.1101/2020.12.28.424618.
  5. Anwesha Deep Dutta, Ajay Kumar, Kiran Lokhande,ManmohanMitruka, Jayanta K Pal, Sachin C Sarode, Nilesh Kumar Sharma. (2020). Detection of oncometabolites 1-methylnicotinamide, nicotine imine and N-Methylnicotinium in nails of oral cancer patients and prediction of them as modulators of DNMT1. medRix (Preprint). https://doi.org/10.1101/2020.09.20.20198101.
  6. Kiran Bharat Lokhande, Tanushree Banerjee, K Venkateswara Swamy, Manisha Deshpande. (2020). An in Silico Scientific Basis for LL-37 as a Therapeutic and Vitamin D as Preventive for Covid-19. chemRxiv (Preprint). https://doi.org/10.26434/chemrxiv.12928202.