Neuro-Oncological diseases are among the deadliest form of cancer. These disease consist of brain and spinal cord neoplasms including astrocytomas, gliomas, glioblastoma multiforme, ependymoma, and brain stem tumors. Brain metastasis is one of the lethal causes of cancer related mortality which even outnumbers the primary tumor in central nervous system (CNS) while glioblastoma being known as the most frequent tumor in brain and aggressive among all human cancers. Current therapies have major ramifications including disruption of brain vasculature and neurodegeneration. We intend to restore the Neuroplasticity and Regenerative capability of these tumors using the Precision medicine based combination therapy approach. A proteomic based molecular and computational analysis is being developed for novel biomarker identification that is extremely beneficial in being utilized to decipher the signalling mechanism involved. The future calls for exploring more of such techniques to develop personalized anti-cancer therapies for achieving the greater goal of human welfare.