Cell as a basic unit of living systems, broad classification of cell types: bacteria, eukaryotic microbes, plant and animal cells; cell, tissue, organ and organisms, Cell organelles: Ultrastructure of cell membrane and function, Chromosomes: Structural organisation of chromosomes, nucleosome organization, euchromatin and heterochromatin. Cell division and cell cycle, Cell–cell interaction, apoptosis, necrosis and autophagy, Cell differentiation.
History, scope and significance of Genetics. Mendelian laws of inheritance. Lethality and interaction of genes. Linkage and crossing over. Mapping of genes. Basic microbial genetics, Genetic mapping. Classical and modern concept of gene, Mutations, Chromosomal aberrations. Genetic disorders in humans. Sex determination in plants and animals. Non disjunction as a proof of chromosomal theory of inheritance. Sex linked, sex influenced and sex limited inheritance. Extra chromosomal inheritance; cytoplasmic inheritance, Mitochondrial and Chloroplast inheritance. Principles of Population genetics; Hardy-Weinberg equilibrium law, Gene and genotype frequencies.
Recommended Books:
- An Introduction to the Molecular Biology of the Cell, Alberts, B., Bray, D., Johnson, A., Lewis, J., Roff, M., Robert, K., Walter, P., Roberts, K., Pub: Garland Publishing Company.
- Cell and Molecular Biology, Sheelar, P., Bianchi, D. E., Pub: John Wiley.
- Molecular Cell Biology, Lodish, H., Berk, A., Zipursky, S.L., Matsudaura, P., Baltimore, D., Danell, J., pub; W.H. Preeman and Company.
- Principles of Genetics, Gardner, E. J., Pub; John Wiley & Sons Inc.